tem 10 10 of 16> In 2000 scientist identified and elucidated the structure of 4
ID: 139974 • Letter: T
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tem 10 10 of 16> In 2000 scientist identified and elucidated the structure of 4 surface proteins on HIV. With this information scientists in 2001 produced 4 protein based vaccines against the HIV virus based on the 4 target (00a-00d) surface proteins shown in HIV-2000. With this information 4 select groups of test subject's were inoculated with one of the 4 vaccines based on the surface protein target 00a-00d. However, by 2015, due to the high mutation rate of HIB the test subjects had the actual surface proteins shown in HIV-2015 (labeled target 15a-15d) Initial results showed that all 4 vaccines resulted in antibodies for the surface protein targets in the target groups Structural changes of 4 HIV surface proteins over time HIV-2000 HIV-2015 target 00a target 15a target 00d target 00b target 15d target 15b target 00c target 15c Predict in order which of the groups vaccinated for one of the four targets 00a, 00b, 00c, or 00d would have the highest immunity for the targets shown in the 2015 HIV virus. Rank from weakest to strongest immunity for the 2015 HIV virus. To rank items as equivalent, overlap them. Reset Help Target group 00a Target group 00b Target group 00d Target group 00c Weakest immunity to 2015 HIV virus Strongest immunity to 2015 HIV virusExplanation / Answer
Immunity, in this case, will be according to the sites completely occupied by antibody binding site to the antigen. An antigen and antibody reaction works like a lock and key mechanism. In this reaction, the epitopes of antigen react with paratopes of the antibody-forming antigen-antibody complex. Thus antigen-antibody reaction is an extremely specific reaction.
As in the question figure given above target, 00a has the maximum matching target with 15 a. Hence it has the highest affinity towards its target. Next, highest affinity would be of 00c as it is little bit matching with its target 15 c. After that target 00d which matches very little to target 15d and least affinity would be of target 00b which does not match its target 15b at all.
Thus from weakest to strongest targets-
target 00b < target 00d < Target 00c < target 00a
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