uestion extreme \"uncoordinated\" phenotype, where the worm completely loses its
ID: 136344 • Letter: U
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uestion extreme "uncoordinated" phenotype, where the worm completely loses its ability to move. Examination of 100 individuals with homozygous genotype unc-37/unc-37 reveals that 58 of them cannot move at all, 25 a show very reduced ability to move, and the remaining 17 seem to have completely wild-type movement. These observations suggest that this unc-37 mutant has n the nematodec. elegans, homozygosity Tor an unc-3r mutant allele can cause an A. a second site enhancer mutation. B. incomplete expressivity C. incomplete penetrance and variable expressivity D. low expressivity and high penetrance. E. low penetrance. Part 3: Short answer (50 total points for this section Question 3.1 (12 total points): A cross is made between an Hfr strain that is Str abd and an F strain that is Str abd. Interrupted-mating studies show that b enters the recipient strain last, and that the Str locus is very far away from b, so it never enters the recipient strain. The b' recombinants are then tested for the presence of the a and d alleles. The following data were obtained a b d 326 a bd 14 400 Write the gene order of the Str, a, b, and d genes beginning with the origin of transfer. (4 points) What is the map distance between markers a and d? (4 points) What is the map distance between markers b and a? (4 points)Explanation / Answer
Ans: 2.11
The answer is b: second enhancer mutation
Unc37 is a transcription factor that interacts with Unc 4 which governs motor neuron identity and mls1which governs uterine muscle specification and formation. (reference: pubmed 10557206) . Uncle 37
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