The immune system responds differently to pathogens that infect intracellularly,
ID: 135433 • Letter: T
Question
The immune system responds differently to pathogens that infect intracellularly, such as viruses, than it does when responding to extracellular pathogens, like most bacteria.
The MMR vaccine is a combination vaccine used against three viruses. Our bodies develop immunity through a series of steps that result in the activation of cytotoxic T cells against virally-infected cells. Place the following steps for T cell activation in the correct order.
First Step to Last Step:
Options:
A helper T cell binds to
the MHC-II protein of
an infected dendritic cell.
The dendritic cell secretes
IL-12 to differentiate
the helper T cell into
a type 1 helper T cell.
Dendritic cells infected with
the virus migrate to
lymph nodes.
Activated cytotoxic
T cells undergo
clonal expansion.
The type 1 helper
T cell secretes IL-2
to activate the cytotoxic
T cell.
Activated cytotoxic
T cells self-stimulate
and leave the lymph node.
A cytotoxic T cell binds to
the MHC-I protein of
an infected dendritic cell.
Explanation / Answer
Answere : The exact sequence of the T-cell activation is :
I. Dendritic cells infected with the virus migrate to the lymph node.
iI. A helper T cell binds to the MHC-II protein of infected dendritic cell.
III. The dendritic cell secretes IL-12 to differentiate the T-helper cell into type 1 helper cell.
IV. The type 1 helper T Cell secrete IL-2 to activate the cytotoxic T cell.
V. A cytotoxic T cell bind to the MHC-I protein of an infected dendritic cell.
VI. Activated cytotoxic T cell undergo clonal expansion.
VII. Activated cytotoxic T cell self stimulate and leave the lymph node.
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