2 Answer the following questions about cell signaling based on the figure below.

Question

2 Answer the following questions about cell signaling based on the figure below. OUTSIDE OF CELL knase growh factors plasma membrane GAP Ras Ras GAE 90 GDP GTP NUCLEUS MEK CYTOPLASM Transcription a. Where does the ligand (in this case, growth factor) bind? b. Where is Ras located? What does it bind to become active? What is the role of GAP? d. What is a negative regulator of this pathway that is not shown in the figure above? Where does ERK go after it is phosphorylated? What does it do there? e. . Describe one activating mutation that affects this pathway.

Explanation / Answer

12.

A) the ligand or the growth factor binds on the tyrosine kinase receptor

B) Ras is referred to as the neuronal network that would be present in the brain stem which would be projecting in the hypothalamus in an anterior manner. It binds to GDP for becoming active

C) GAP is the GTPase activating protein which would be stimulating activity of the enzyme resulting in termination of the event.

D) neurofibromin 1 is the negative regulator of the Ras pathway.

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