ATIONAL CENTER FOR CASE STUDY TLACHING IN SO Part lI-How Could a Virus Have Ente

Question

ATIONAL CENTER FOR CASE STUDY TLACHING IN SO Part lI-How Could a Virus Have Entered Terry considered what she had learned so far. "So the Ebola virus could be inside my celle But how? How exacdy could a virus get inside? It seems to start at the plasma membran... I'd better keep reading In the first step of infection, vinal proteins interact specifically with hont cell. Different siuses like influenza, rabies and even Ebola tach have unique glycoproteini em ? eir sufact that bind only to pecific receptors on the particular host cells they infect. For example, she infuenzs virus wies the HA (hemagclutinin) protein for binding to the host cell recepters on respinatory epithelial cells. A rabices virus relies on the G protein protruding out of its vinal envelope se anach to the hest cell receptors of neurens. Ebola virus uses GP to bind to the host cell recepters en a wide variety of cell, beginning swiah the macrophages and dendritic cell of the lymphatic ystem. Once viruses anach so she bost cell in this very pecific manner, there are three major was for them to compiete the second stage of infection, entr into the boit cel The firt is by direct injection ofitn genome (DNA or RNA)ie the het cell at thr ell surface The second is the binding of the virus no the plarma membrane. folloued by the farion of the vinal envelope with the to cell. The third way is for the viras to bind to the host cell membrane and become internalized inte the host cell via the endocytic pathuay best membrane to transfer the viral genome (DNA or RNA) into the hest "This is very strange," she thought. Questions 1. Why is viral attachment to the host cell specific berween one virus and one type of cell 2. List several types of host cells and the associated virus that binds to the host cell 3. What are three major ways in which a virus enters a host cell to deliver its genome? 4. Formulate a hypothesis as to why there is more than one mechanism of viral entry into host cel

Explanation / Answer

Questions

1. Why is viral attachment to the host cell specific between one virus and one type of cell:

Viruses are highly specific to the cells they infect as viruses must bind precisely to proteins on the cell surface and proteins of viruses will bind with specific receptors. It must be a specific cell for that only specific virus. And then virus use a host genetic system.


2. List several types of host cells and the associated virus that binds to the host cell.

a) HIV- Natural killer cells
b) T-Cells Influenza which attaches to lung cells


3. What are three major ways in which a virus enters a host cell to deliver its genome?

a) Direct injection

b) Binding of the virus to the plasma membrane which is followed by fusion of viral envelope.

c) Virus binding to whole cell membrane and internalized in the cell.


4. Formulate a hypothesis as to why there is more than one mechanism of viral entry into host cells.

It does not match with receptors or it has certain type of cells for infection. The virus does not attach to cell as it does not fit the specifications that it has.

Related Questions

Navigate

• Browse (All)
• Browse A
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.