Sapling Learning There is more than one correct statement. Check all the true st

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Sapling Learning There is more than one correct statement. Check all the true statements This syndrome is caused by a deficiency in 5-phospho-o-ribosy-1 This deficiency does not áflow purine nucleotide production via the salvage pathway (PRPP) Some symptoms of Lesch-Nyhan syndrome include involuntary movements and selif-mutilation. Uric acid is produced in excess with this syndrome, and in excess it acts as a prooxidant Gout causes Lesch-Nyhan syndrome 2 Incorrect. Exit # Try Again Next O Previous Give Up & View Solution Explanation

Explanation / Answer

Lesh-Nyhan syndrome is caused due to deficiency of the enzyme Hypoxanthine-guanine phosphoribosyl transferase (HGPRT), a key enzyme in the purine salvage pathway, characterised by neurological symptoms and self-mutilating behaviour.

The decresed utilization of purines leads to high levels of uric acid. Uric acid crystals accumulates in the joints and kidneys and causes gout.

hence, statements 2,3 and 4 are correct. options 1 and 5 are incorrect as it is not caused due to deficiency of PRPP and Gout is a result of Lesh-Nyhan syndrome.

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