The amount of cyclins fluctuates throughout the cell cycle, while the amount of

Question

The amount of cyclins fluctuates throughout the cell cycle, while the amount of CDKs remains relatively constant. However, the kinase activity of CDKs is stimulated once they are bound to cyclins, therefore, CDK activity changes throughout the cell cycle and is responsible for driving the cell to the next stage. Based on the figures below, answer the following questions 1. Ctk Cyclin B/CDK1 Cyclin D/CDKA/6 G1 Cyclin E/COK2 Cyclin A/CDK1 Cyclin A/CDK2 a. Which cyclin is at the highest concentration during: G1 phase Bridge between G1 and S phases Bridge between S and G2 phases Bridge between G2 and through mitosis b. Which cyclin(s) stimulate the following cyclin-dependent kinases? CDK1 CDK2 CDK4

Explanation / Answer

Cyclin is at higher concentration during

G1 = cyclin D

Bridge between G1 and S phase= cyclin E

Bridge between S and G2 phase= cyclin A

Bridge between G2 and through mitosis= cyclin B

Cyclins stimulated the following cyclin dependent kinase

CDK1 = cyclin B

CDK2 = cyclin E

CDK4 = cyclin D

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