Soon we will be talking about the phenomenal enzymes of glycolysis and the TCA c

Question

Soon we will be talking about the phenomenal enzymes of glycolysis and the TCA cycle. Between these two pathways occurs a step (often called the transition step) in which the enzyme called pyruvate dehydrogenase converts a three carbon molecule (pyruvate) to a two carbon molecule (acetyl - CoA). Interestingly, the enzyme pyruvate dehydrogenase is heavily regulated. The following image shows one way in which it is regulated: Notice particularly that when pyruvate dehydrogenase is phosphorylated it is inactive. When it is dephosphorylated, it is active. Thus we can draw which

Explanation / Answer

Correct Answer: (B) Pyruvate dehydrogenase is regulated via covalent modification As stated in the question the thing that makes pyruvate dehydrogenase active or inactive is the addition or removal of a phosphate group. The addition or removal of a phosphate group is a type of covalent modification and therefore answer choice (B) is the correct answer

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