1.) (50 points) You have been hired as a biomaterials expert by a consulting com
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Question
1.) (50 points) You have been hired as a biomaterials expert by a consulting company to help develop a line of replacement hearts. You are instructed to consider two approaches: 1) Total artificial heart (TAH) and 2) Tissue engineering approach. Describe how you would construct a heart using the two approaches and specify which types of materials would be used for each case and the particular features of each class of materials that would make them suitable for use in developing the two types of hearts. What types of tests would you conduct on a completed heart to ensure safe integration and performance in the body?Explanation / Answer
Implants and biomaterials for cardiovascular tissue engineering
Synthesis Biologic
Metals Polymers Ceramics Cell based ECM based whole tissue based
-Titanium -Bio glass -Immature cells -Auto graft
-Stainless steel -Mature cells -Homograft
-Gold
-Silver Decellularized ECM cells
-Nitinol -Collagen
-Cobait chromium Allo graft Xeno graft -Fibrin
-Platinum chromium -SIS -Chitoscan
-Pericardium -Alginate
-Valves
Non-reabsorbable Bio-reabsorbable -Blood vessels
-PU -PLA -PGLA
-PTE -PGA -PCLA
-PTFE -PCL -PGS
Artificial
(Combination of synthetic and natural biomaterials)
Tests needed on a completed heart to ensure safe integration and performance in the body:
The below tests are needed to ensure safe integration and performance of the heart:
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