A biotech company is exploring three novel treatment options for type 2 diabetes

Question

A biotech company is exploring three novel treatment options for type 2 diabetes: Drug A, Drug B, and Drug C. To test how effective these drugs are in treating type 2 diabetets, they treat a mouse model of type 2 diabetes (T2D) with either the drug (labeled treated) or a negative control of saline (labeled saline). They also treat normal wildtype mice (Wt) with either the drug or saline. Please evaluate the following data from the experiments for Drug A, Drug B, and Drug C.

Based on these data, which of these drugs would you NOT recommend to pursue as a treatment for type 2 diabetes?

Drug B Drug A 12 12 -T2D-Treated 2D-Saline Wt-Treated Wt- Saline T2D . Treated T2D- Saline wt-Treated Wt - Saline 25 10 15 20 Days of Treatment 10 Days of Treatment Drug C 2 10 T2D-Treated T2D-Saline wt-Treated Wt-Saline 0 10 15 Days of Treatment

Explanation / Answer

From the graphs we can see that Drug A lowers the blood glucose concentration. We can say that from the negative control of saline that could not lower the blood glucose concentration. So we can use drug A for the treatment.

Same case is for the Drug B that lowers the blood glucose concentration. So it can also be used for the type-2 diabetes treatment.

Drug C when compared to the negative control did not lower the blood glucose concentration. So drug C can't be used to treat the type-2 diabetes.

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