True or False. 1. Activated Gs interact with PLC-beta to produce phosphatidylino

Question

True or False.
1. Activated Gs interact with PLC-beta to produce phosphatidylinosital 3,4, 5- triphosphate and diacylglycerol.

2. EGF is an example of hormone

3. Ras is an example of the heterotrimeric G protein

4. All members of the G protein coupled receptors have a kinase domain in the cytoplasmic tall domain.

5. Wnt is an example of the ligand for the RPTK family.

6. GEF activates GPCR receptors.

7. PH domain containing proteins bind to an activated PDGFR.

8. Ligands for GPCR proteins induce dimerization of the receptor.

9. Grb2 is an adaptor protein that binds to a phospho-tyrosine residue of an activated PDGFR through a SH3 domain.

10. When a cell has a dominant negative Ras mutation, an introduction of a constituitively active RPTK mutant will allow Ras signaling.

11. PLC will generate IP3 and DAG from PIP3.

12. Calcium inhibits PKC.

13. cAMP activates PKA.

14. Delta binds to Patched.

15. TGF signal stabilizes beta catenin transcription factor.

16. The Notch tail can function as a transcription factor.

17. Wnt signaling destabilizes -catenin through GSK3 mediated phosphorylation.

18. Pertussis toxin modifies Gi protein.

19. MAP kinase activates MAP kinase kinase (MAPKK).

20. cAMP is an example of a second messenger.

21. Adherence junction is enriched with intermediate filaments.

22. Intermediate filaments are permanent structures that cannot be dissessembled in any case.

23. Plectin cross links only the intermediate filaments.

24. - tubulin has an ATPase activity.

25. ARP2/3 is the nucleating protein for the 70 degree branched microtubule structures.

26. Formin is the nucleating protein for the branched filamentous actin structures.

27. Thymosin binds to a tubulin dimer, and prevents its addition to the plus end.

28. EB1 binds to the minus end of the microtubule.

29. Microtubules can be severed in the middle by severeing proteins such as Gelsolin.

30. A moleculor motore Dynein moves to the positive end of the microtubule.

31. Actin has a GTPase activity.

Explanation / Answer

1. False 2. True 3. True 4. False 5. False 6. False 7. False 8. True 9. True 10. False 11. True 12. True 13. False 14. False 15. True 16. True 17. False 18. False 19. True 20. True 21. True 22. True 23. True 24. False 25. False 26. False 27. True 28. True 29. False 30. True 31. True

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