Biochemistry: Why might a person have elevated levels of pyruvate AND lactate? (

Question

Biochemistry: Why might a person have elevated levels of pyruvate AND lactate? (select all answers that apply)

a.) because his/her body is doing lactic acid fermentation

b.) because he/she is hypoglycemic and is producing ketone bodies

c.) because he/she is in a fasted state and his/her liver is running gluconeogenesis to produce pyruvate for the brain

d.) because there might be a problem with the pyruvate dehydrogenase complex resulting in a surplus of pyruvate in excess of what is needed for lactic acid fermentation

Thanks!

Explanation / Answer

The correct answer is d.As pyruvate dehydrogenase complex converts pyruvate to acetyl Co A and which goes to kreb cycle but if there will be a problem with complex then the level of pyruvate will increase and it will be converted to lactate by lactate dehydrogenase hence its level will also increase.

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