2. The enzyme PFK- 1 catalyzes the 3d step in the glycolytic pathway (as shown b

Question

2. The enzyme PFK- 1 catalyzes the 3d step in the glycolytic pathway (as shown below) and is known to be an allosteric protein with multiple regulatory sites. Shown below is a grap PFK-1 activity (defined as a % of it's V) vs. the [ATP] Given this data and information describe why PFK-1 activity increases sharply at lower [ATP] and then experiences a steady decline in activity as [ATP] increases passed a threshold level. (5 points) fructose-6-phosphate + ATPfructose-1,6-bisphosphate + ADP AG=-22.2 kJ/mol 100 80 60 40 20 ATPI

Explanation / Answer

2. The enzyme PFK- 1 catalyzes the 3d step in the glycolytic pathway (as shown b

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