2. The conversion of fumarate to malate is catalyzed by the enzyme fumarase fuma

Question

2. The conversion of fumarate to malate is catalyzed by the enzyme fumarase fumarase Fumarate H2OMalate The value of AHR is-20 kJ/mol, the value of AH is 41.3 kJ/mol, and the value of AS in the enzyme active site is -16 J/mol*K. Draw the reaction coordinate diagram to scale, Calculate the activation energy of the FORWARD and REVERSE reactions (both), and Calculate the forward rate constant at 298 K 3. The kinetics of the base-catalvzed reaction I (aq) + OCI (aq)- Cl (aq) were studied at 25 °C. Experimental information from a study are shown below: OH]o [OCIJo (mM 1.5 1.5 Initial Rate (M.s 1.8x10 3.6x10 1.8x10 7.2x10 o (mM 2 4 2 4 2 Derive the RATE LAW and calculate the RATE CONSTANT with correct units

Explanation / Answer

3) order w.r.t, I-

   r1/r2 = (a1/a2)^x

(1.8*10^-4/(3.6*10^-4)) = (2/4)^x

   x = 1

order w.r.t, OCl-

   r2/r4 = (a2/a4)^y

   (3.6*10^-4/(7.2*10^-4)) = (1.5/3)^y

   y = 1

order w.r.t, OH-

from 1,3 trails I- is constant , and ocl- , oH - is doubled,but no chnage in rate means

by chnaging ocl- concentration rate is doubled,at the same time bu changing oH- rate becomes half.

   therefore, order w.r.t OH- = - 1

rate law, rate = k[I-]^1[OCl-]^1[OH-]^-1

over all order of reaction = 1+1-1 = 1

rate constant(k) = rate /[I-]^1[OCl-]^1[OH-]^-1

                   = 1.8*10^-4/(2*1.5*1^-1)

                   = 6*10^-5 s-1

Related Questions

Navigate

• Browse (All)
• Browse 2
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.