2002, Chap. 14, p. 974 and references therein. of an Arene Sulfonamide: Sulfanil

Question

2002, Chap. 14, p. 974 and references therein. of an Arene Sulfonamide: Sulfanilamide on names: sulfanilamide, p-aminobenzenesulfonamide Experiment C3 CA number: [63-74-1] CA nam e as indexed: benzenesulfonamide, 4-amino- The sequential synthesis is completed and the sulfa drug, sulfanil- Purpose. mide is obtained by treatment of the sulfonyl chloride intermediate prepared n Experiment [C2j, with an aqueous ammonia solution.2 This interesting product is fully characterized. Prior Reading Technique 5: Crystallization Use of the Hirsch Funnel (pp. 88-89) Craig Tube Crystallization (pp. 89-91) experiment is adapted from the work of S. Danishefsky, Yale University (personal com- munication)

Explanation / Answer

Nucleophilic reagents are electron rich substance contains atoms which have atleast one unshared pair of electrons.

Factors contributing nucleophilicity are

Charge

Electronegativity

Solvent

Steric hundrence

Here preparations are done in ammonia solution ammonia is a protocol solvent so that can donate hydrogen ions to reagents.because of the solvent effect ammonia is more nucleophile than OH.

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