a key enzyme in glycolysis and S. in the liver, S. Iin the liver, which of the f

Question

a key enzyme in glycolysis and S. in the liver, S. Iin the liver, which of the following is an allosteric effector molecule that both activates inactivates one in gluconeogenesis? A) NADH B) citrate C) ATP E) Fructose-1,6 bisphosphate 6. Protein kinase A (PKA) activation requires A) slucagon or epinephrine hormone action B) cyclic AMP (CAMP) C) G-protein function D) All of the above E) None of the above 7. Which of the following is true of glycogen synthesis and breakdown? A) For metabolic efficiency, synthesis and breakdown are catalyzed by the same enzymes. B) Glucose units are added to glycogen at its reducing end. C) The cytoplasm is the location for both processes D) The immediate product of glycogen breakdown by glycogen phosphorylase is glucose E) Under normal metabolec circumstances, glycogen synthesis and glycogen breakdown occur simultaneously and at similar rates. 8. Which enzyme is targeted by drugs such as statins to lower cholesterol concentrations in humans? A) Acetyl-COA carboxylase B) HMG-CoA synthase C) HMG-CoA reductase D) HMG CoA lyase E) Thiolase 9. In the catabolic metabolism of fatty acids, the carbon atoms from a fatty acid with an odd number of carbons enter the TCA cycle as acetyl-CoA and A) succiny-CoA B) citrate D) malate E) a-ketoglutarate 10. Which of the following enzymes is/are used in gluconeogenesis? A) hexokinase B) PEP carboxykinase C) pyruvate carboxylase D) A and B only E) B and C only CHEM 432 Exam3

Explanation / Answer

1)D Fructose-2,6-bisphosphate.This is the allosteric regulation of both processes. Fructose-2,6-bisphosphate promotes glycolysis and slows gluconeogenesis by allosterically regulating the enzymes PFK and FBPase.

6 BcAMP

7) c cytoplasm is the location for both

glucose is added to non reducing end.immediate product of phosphorylase catalysed reaction is Glucose1phosphate. Both processes do not occur at same rates

8) C HMG-CoA reductase

Statins and other similar molecules act by competitively inhibiting HMG-CoA reductase, the rate-limiting enzyme of the mevalonate pathway.

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