7. Male cockroaches with mutations that strongly decrease the function of an RTK

Question

7. Male cockroaches with mutations that strongly decrease the function of an RTK called RTKX are oblivious to the charms of their female comrades. This particular RTK binds to a small molecule secreted by sexually mature females. Most males carrying loss-of-function mutations in the gene for Ras protein are also unable to respond to females. You have just read a paper in which the authors describe how they have screened cockroaches that are mutant in RTKX for additional mutations that partly restore the ability of males to respond to females. These mutations decrease the function of a protein that the authors call Z. Which of the following types of protein could Z be? Explain your answer.

(a) a protein that activates the Ras protein by causing Ras to exchange GDP for GTP

(b) a protein that stimulates hydrolysis of GTP by the Ras protein

(c) an adaptor protein that mediates the binding of the RTKX to the Ras protein

(d) a transcriptional regulator required for the expression of the Ras gene

(I think its B but I dont have a good explanation why its B and im not 100% sure it is B. If it is B please explain why B is correct and if it isnt please explain why that answer is correct instead.)

Explanation / Answer

ANSWER:

Given,

Male cockroaches with mutations that strongly decrease the function of an RTK called RTKX are oblivious to the charms of their female comrades. This particular RTK binds to a small molecule secreted by sexually mature females. Most males carrying loss-of-function mutations in the gene for Ras protein are also unable to respond to females.

(b) a protein that stimulates hydrolysis of GTP by the Ras protein

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