.\'ll AT&T; 2:09 PM @ 50%. EXTRA CREDIT.docx 2.10 386 9.82 2.10 4.07 947 2.32 9.
ID: 1025033 • Letter: #
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.'ll AT&T; 2:09 PM @ 50%. EXTRA CREDIT.docx 2.10 386 9.82 2.10 4.07 947 2.32 9.76 NA 2.18 9.04 1248 5. Which solution contains an amino acid that would be most likely to stabilize an anionic substrate in an enzyme pocket at physiological pH? A) solution b) solution 2 c) solution 3 d) solution 4 6. The antibiotic chloramphenicol is a competitive inhibitor of an enzyme involved in translation elongation. Using knowledge of Michaclis-Menten kinetics, what effect would the addition of c of its target enzyme? a Vmax decreases, Km increases b) V max decreases, Km remains unchanged c) Vmax remains unchanged, Km increases d) V max remains unchanged, Km decreases hloramphenicol l have on the kinetics 7. Platelets carry 95% of blood serotonin. Serotonin functions as a hormone and neurotransmitter in many systems. Researchers believe that platelet serotonin may play a role in the observed positive effect of platelets upon hepatocyte proliferation. The chemical structure of serotonin is shown below: Where are the serotonin receptors most likely to be located in hepatocytes? A) in the nucleus b) in the cytosol c) embedded in the mitochondrial membrane d) embedded in the cell membrane 8. Based on the information given in question 7, the amino acid precursor of serotonin is best described as having which type of R-group? A) nonpolar, aliphatic b) Polar, uncharged c) aromatic d) Negatively charged Open With PrintExplanation / Answer
ANswer 5.
The solution 4 will have an amino acid which will stabilize the anionic substrate as it has pKa of 12.48. This means it has a basic side chain, which can be used to stabilize anionic substrate via ionic interactions.
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