A new human disease has been identified in which proteins normally secreted at t

Question

A new human disease has been identified in which proteins normally secreted at the plasma membrane are trapped within the cytoplasm (apparently in anterograde transport vesicles). 3 different drugs have been proposed to treat the disease.

DRUG A ensures the proper formation of actin filaments.

DRUG B enhances ATP biosynthesis.

DRUG C enhances protein transport across the RER membrane into the ER lumen.

As the expert on cell biology, you have been asked to evaluate EACH drug for potential efficacy (i.e. could the drug POSSIBLY correct or treat the disease).

Explanation / Answer

Protein secretory pathways in the cell occurs in the following order,

Rough endoplasmic reticulum -- golgi transport vesicles -- golgi cisternae -- secretory or transport vesicles -- cell surface -- protein secretion by exocytosis

Actin is required for the movement of molecules and proper functioning of golgi apparatus. Therefore, the drug A which ensures the proper formation of actin filaments can modify the defect in the protein secretory pathway.

The priming of secretory vesicles require ATP. Therefore, the drug B which increases ATP biosythesis is useful in this scenario.

The protein has to be transported into the lumen of ER from RER membrane during the process of cotranslation. Therefore, the drug C which enhances the protein synthesis across the membrane into the lumen of ER can modify the disease.

Related Questions

Navigate

• Browse (All)
• Browse A
• Subjects

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.