Equation 1. 2. Early experiments by Hodgkin and Huxley indicated that changes in
ID: 1022959 • Letter: E
Question
Equation 1.
2. Early experiments by Hodgkin and Huxley indicated that changes in external or in ternal Na concentration had reversible effects on the peak amplitude of the action otential. Results of modifications in the internal and external Nat concentrations showed only small changes in the resting membrane potential. By assuming the values of resting conductances and unperturbed resting membrane and reversal po- tentials of Table 1 estimate the changes in resting membrane potential in response (a) reducing extracellular Na+ concentrations to 33%, 50% and 71% of the normal (seawater) values, assuming that the extracellular fluid is maintained to be isotonic by the addition of glucose (b) increasing intracellular concentrations of Nat by replacing 1/4, 1/2 and 3/4 of the intracellular potassium with Na+Explanation / Answer
The Hodgkin–Huxley model, or conductance-based model, is a mathematical model that describes how action potentials in neurons are initiated and propagated. It is a set of nonlinear differential equations that approximates the electrical characteristics of excitable cells such as neurons and cardiac myocytes, and hence it is a continuous time model, unlike the Rulkov map
The relatively static membrane potential of quiescent cells is called the resting membrane potential (or resting voltage), as opposed to the specific dynamic electrochemical phenomena called action potential and graded membrane potential.
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