A number of inhibitors of respiratory chain exist (See Fig. 21.20), some quite d

Question

A number of inhibitors of respiratory chain exist (See Fig. 21.20), some quite dangerous. Consider the following inhibitors:

1) Rotenone, which inhibits electron flow from NADH-Q oxidoreductase to ubiquinone.

2) Antimycin A, which blocks electron flow between cytochrome b and cytochrome c1

3) Cyanide, which blocks electron flow between cytochrome c oxidase to O2

Assuming that plenty of NADH is available but that FADH2 availibility is highly limited, which of the following specifically describes the redox state ofcytochrome C upon (individual) administration of these inhibitors to mitochondria? The numbers in the answers correspond to those above.

Explanation / Answer

Answer 1) reduced 2) reduced 3) reduced

Explanation. When chain is blocked then all intermediates on substrate side become reduced and on oxygen side become oxidized.

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