a) Which drug is probably a placebo? Explain. b) Give a plausible explanation wh

Question

a) Which drug is probably a placebo? Explain.

b) Give a plausible explanation what each of the three other drugs might do, giving cellular and/or chemical details.

Will give a thumbs up if correct, thank you.

3. You have four identical Isolated neurons which are capable of forming excitatory ACh synapses on both ends. You treat each of these neurons with a different drug. You then apply acetylcholine to the dendrites of each neuron, and test to see if that neuron is capable of EPSP formation, action potential production, and/or acetylcholine release. The results to your studies are given here: Neuron EPSPs? Ach APs? released? #1 (Drug A) #2 (Drug B) #3 (Drug C) HA (Drug D) yes no yes yes yes no no yes no no no yes

Explanation / Answer

When a motor neuron generates an action potential, it travels rapidly along the nerve until it reaches the neuromuscular junction, where it initiates an electrochemical process that causes acetylcholine to be released into the space between the presynaptic terminal and the muscle fiber. The acetylcholine molecules then bind to nicotinic ion-channel receptors on the muscle cell membrane, causing the ion channels to open.

an excitatory postsynaptic potential (EPSP) is a postsynaptic potential that makes the postsynaptic neuron more likely to fire an action potential. This temporary depolarization of postsynaptic membrane potential, caused by the flow of positively charged ions into the postsynaptic cell, is a result of opening ligand-gated ion channels.

Drug A is capable of generating EPSP and AP but not acetylcholine release then probably it is a pacebo as it acts like a drug but does not causes any electrochemical process to occur.

Drug D is a potent drug causing every step of nerve impulse generation.

Drug C can generate EPSP this means it is able to cause the flow of positively charged ions into the postsynaptic cells.BUt later on no AP is generated.

Drug B is not a potent drug as it does not geneartes any neuronal activity.

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