Lactose is a disaccharide found in milk. Although in the United States we are to
ID: 1000519 • Letter: L
Question
Lactose is a disaccharide found in milk. Although in the United States we are told that "mille, it docs a body good," many adults throughout the world get sick from drinking milk because they cannot digest lactose. When someone who is lactose intolerant ingests milk, the lactose accumulates in the lumen of the small intestine because there is no mechanism for uptake of the disaccharide. This causes abdominal distension, cramping, and watery diarrhea. Why does the accumulation of sugar (or any solute) in the intestinal lumen cause an influx of water that leads to watery diarrhea? Adults who can drink milk can do so because of the enzyme lactase which is located on the outer surface of epithelial cells lining the small intestine. Lactase hydrolyzes lactose into its two component monosaccharide's, glucose and GA lactose. Both glucose and GA lactose can cross the epithelial cells, and therefore do not cause illness. You decide to study lactase further, and see whether it can also cleave other common disaccharides, such as maltose. (Maltose glucose * glucose.) You find that maltose is NOT cleaved by lactase, and furthermore, maltose appears to have some kind of inhibitory effect on lactase's ability to cease lactose. Is maltose a more likely candidate for competitive or noncompetitive inhibition of lactase? explain.Explanation / Answer
A. probaly this is due balencing of osmotic pressure. Once solute accumulate the osmotic pressure in track increase so to reduce that water eflux take place.
B. Since moltose and lactose have similar type of structure only certain difference in steriochemistry so, moltose is competitive inhibitor.
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