Fill in the blanks with True (T) or False (F) for each of the given statements.

Question

Fill in the blanks with True (T) or False (F) for each of the given statements.

It is possible to directly form an acyl anion with an aldehyde and base.

Electrophilic aromatic substitution is always faster with a heterocycle than with benzene.

Pyridines are electron poor aromatic rings and are particularly good at nucleophilic aromatic substitution.

Heterocyclopentadiene undergo electrophilic aromatic substitution primarily at the C-3 position.

1,3-diester is less acidic than a 1,3-ketoester, which is less acidic than an 1,3-diketone due to increased electron donation by the -OR group of the ester.

Claisen reactions use a stoichiometric amount of base and do not polymerize, unlike aldol reactions that use a catalytic amount of base and can polymerize.

Beta-hydroxy ketones can be formed by thiazolium catalysis with aldehydes.

Aliphatic heterocycles typically act like normal ethers, amines, and thioethers unless there is a large amount of ring strain.

Explanation / Answer

It is possible to directly form an acyl anion with an aldehyde and base.

False. (We can not make acyl anion)

Electrophilic aromatic substitution is always faster with a heterocycle than with benzene.

True (But maximum it depends what moeity it is)

Heterocyclopentadiene undergo electrophilic aromatic substitution primarily at the C-3 position

True (They electron rich at 3rd position)

1,3-diester is less acidic than a 1,3-ketoester, which is less acidic than an 1,3-diketone due to increased electron donation by the -OR group of the ester.

True (The reason is perfect)

Claisen reactions use a stoichiometric amount of base and do not polymerize, unlike aldol reactions that use a catalytic amount of base and can polymerize.

False (it can not be polymerized)

Pyridines are electron poor aromatic rings and are particularly good at nucleophilic aromatic substitution.

False (Pyridines are basically electron rich aromatic rings)

Beta-hydroxy ketones can be formed by thiazolium catalysis with aldehydes

False (Diketones are forming via thiazolium catalysis called Stetter Reaction)

Aliphatic heterocycles typically act like normal ethers, amines, and thioethers unless there is a large amount of ring strain.

.True

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