Which of the following binding constants represents the lowest affinity? K_a = 1

Question

Which of the following binding constants represents the lowest affinity? K_a = 1.0 Times 10^7 M^-1 K_a = 1.0 Times 10^-10 M^-1 K_d = 1.5 Times 10^-9 M^-1 K_a = 2.0 Times 10^8 M^-1 K_d = 1.0 Times 10^-9 M In the chymotrypsin-catalyzed reaction given below, which of the following is established? (This evidence was used to propose a mechanism for the cleavage of a peptide bond by chymotrypsin) Formation of a peptide bond Formation of an acyl-enzyme intermediate Elimination of water Hydrolitic cleavage B and D V = k[S] represents the rate equation for the first-order reaction, where V is the velocity, S is the substrate concentration, and k is the first-order rate constant. If k = 2000 s^-1, the reaction will be almost over in . 10 s 0.5 ms 0.4 ms 0.4 s 0.2 s

Explanation / Answer

Highest Ka and lowset Kd is highest binding affinity.

lowest Ka and highest Kd is lowest binding affinity.

Kd = [P][L]/[PL]

Ka = [PL]/[P][L]

Kd = 1*10-9 M

answer E. Kd = 1*10-9 M

50. V = K[S]

     K =2000sec-1

    t = 0.0005sec

      =0.5ms

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