Problem 3.7 Part B How will the contribution of AS for native denatured affect t

Question

Problem 3.7

Part B How will the contribution of AS for native denatured affect the favorability of the process? What apparent requirement does this impose on AH ifproteins are to be stable structures? Match the words in the left column to the appropriate blanks in the sentences on the right. Make certain each sentence is complete before submitting your answer Reset Help AG AH TAS a value for AS results in a Since contribution to AG (T s always in the Kelvin scale) reduces positive Thus, for proteins to be stably folded (which requires AG to be for the process described in the question), it would appear that AH must be large and ncrease negative AG AH --TAS This is generally true; however, this simple analysis does not consider the effect, which results in a more overall AS hydrophobic hydrophilic Thus, the requirement that AH is large and is not absolute because the hydrophobic effect the magnitude of AS Submit My Answers Give Up

Explanation / Answer

Since dG = dH - TdS, a increase value for dS results in a increased contribution to dG. (T is always positive in the kelvin scale).

Thus, for the protein to be stably folded (which requires dG to be postive for the process described in the question) it would appear that dH must be large and negative.

This is generally true, however this simple analysis does not consider the hydrophobic effect, which results in a more positive overall dS.

The, the requirement that dH is large and negative is not absolute because the hydrophobic effect decreases the magnitude of dS.

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