Which situation would be the most likely result of a mutation in a eukaryotic or

Question

Which situation would be the most likely result of a mutation in a eukaryotic organism that causes it to produce less p21 protein than normal?

Cell replication would be slowed if the organism receives radiation.
Cells with radiation-induced DNA damage would continue through the cell cycle without repairing the damaged DNA.
Cells with incomplete DNA replication would continue through the checkpoint.
Cells would not respond to growth factors.
Cells would have a hypersensitive response to growth factors.

Explanation / Answer

P21 is a cyclin-dependent kinase inhibitor that is capable of inhibiting all cyclin/CDK complexes, though is primarily associated with inhibition of CDK2., p21 acts as an effective inhibitor of DNA S-phase DNA synthesis during DNA damage.Thus with the reduced amount of P21 gene cells with incomplete DNA replication would continue through the checkpoint.

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