Nature Reviews Microbiology 3 , 765-776 (October 2005) | doi:10.1038/nrmicro1284

Question

Nature Reviews Microbiology 3, 765-776 (October 2005) | doi:10.1038/nrmicro1284

1A.After entry, what is the first process labeled “A”?

1B. Which protein complex is doing the process shown in “A”?

1C.Why can this happen as soon as the genome enters the cell?

2. Over on the upper right side of the figure, labeled “B”, why does the virus shut off host cell translation and transcription? What is the benefit of this to the virus?

3. What viral process is happening part C and what enzyme does this?

4. What are the blue lines made in part D and what is the dual purpose of these blue lines?

Pro-apoptotic Anti-apoptotic Shut off host cell Sta 0 host cell (cap Polyprotein Interactions between the vius and the cel cycle ral replication complex dsRNA (atency?) strand (goniome 3 3 3 Cell lysis Veal ogrees Nature Reviews Microbiology 3, 765-776 (October 2005) I dol:10.1038/nrmicro1284

Explanation / Answer

1A. Answer:

After the entry of the receptor the first process is uncoating the receptor so that they can easilty be enter into the RNA.

1B. Answer:

IRES is an internal ribosome entry site which can be helpful for the translation usually for the protein systhesis which takes place at the 5' end and the protein complex used during this translation is  eIF4E protein.

1C. Answer:

As soon as the genome enters the host cell it results into the injection of the viral genatic material into the cell and whatever the DNA or RNA will get attached or incorporated into the host cell which leads to the replication of the viral genome

2 Answer:

As soon as the virus shut off the host cell the host cell will lose its original property and the viral genome which enters into the host cell will suppress the property of the host cell and begin to replicate its own property or characteristics in the form of virus.

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