Two genes, along with their promoters and regulatory elements are represented be

Question

Two genes, along with their promoters and regulatory elements are represented below. The//indicates a distance of more than 1000 nucleotides separating the promoters from the regulatory elements. a. Circle the correct answer in brackets and explain your answer below. If elements A-E provide positive control, then the control elements for both genes are considered [silencer/enhancer/promoter-proximal) elements. b. Assume that clement C is a silencer and elements B, A and D are enhancers. Which combination of regulators will cause a high level of expression for the fantasin gene? Select all that apply. a. A. B, C, D b. A and C c. B and D d. A and B e. A and D c. Assume that element C is a silencer and elements B, A and D are enhancers. Which combination of regulators will cause a high level of expression for the imaginin gene? Select all that apply. a. A. B, C. D b. A and B c. E and D d. A and D e. C and D d. If element A is an enhancer and element C is a silencer, what histone marks would you find associated with elements A and C (in that order)? a. H3K4Me and H3K4Me b. H3K4Mc and H3K9Me c. H3K9Me and H3K4Me d. H3K9Mc and H3K9me

Explanation / Answer

1) a) If the control elements A - E provide positive control, then the control elements for both genes are considered to be enhancers. This is because enhancers are a type of regulatory sequence in DNA that is located at a great distance from promotor and exerts its influence.

b) The regulatory elements present in fantasin gene are A, B and C. C is a silencer sequence and A and B are enhancers. Therefore, combination of A and B genes will cause high level expression of the fantasin gene. The correct answer is option d (A and B).

c) Element C is a silencer. Elements A, B and D are enhancers. Imaginin gene contains D, E and C. Therefore, the combination of D and E genes will cause high level expression of imaginin gene. The correct answer is option C (E and D).

d) The histone marks for enhancer sequences are H3K4me and H3k27ac. Similarly, the histone mark for silencer sequences is H3K9Me. Therefore, the correct answer for this question is option b (H3K4Me and H3K9Me).

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