A hypothetical protein is stabilized by electrostatic interactions between a lys

Question

A hypothetical protein is stabilized by electrostatic interactions between a lysine in alpha helix 1 and an aspartic acid in the neighboring alpha helix 2 as shown below

Does the above interaction involve backbone interactions or side chain (R-group) interactions?

This stabilizing interaction could be an example of (circle all that apply):

i.Primary structure

ii.Secondary structure

iii.Tertiary structure

iv.Quaternary structure

If the pH of the solution was lowered to 3, what effect would that have on the above interaction? What charge would each amino acid have at pH = 3?

Explanation / Answer

the primary structure of proteins are the particular sequence of amino acids which is the backbone of a peptide or protien .

the stabilizing interaction is an example of primary interaction

As we can see NH3+ bond in structure therefore on increasing pH the interaction easily takes place as amino group easily accept proton .

on increasing ph the neutral amino acid lysine is convert into acidic form will no effect on aspartic acid as it is already acidic . if the acidity of aspartic acid is more then ph 3 then its acidity may increase .

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