Desl completes the statement or answers the question. 1. Where do allosteric inh

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Desl completes the statement or answers the question. 1. Where do allosteric inhibitors bind on an enzyme? a. They always bind at a site different from the active site. b. They always bind at the active site. c. They can bind at either active site or another site. d. They always bind directly to the substrate e. none of these 2. Redox reactions often use this cofactor: a. Riboflavin b. Lipoic acid c. Pyridoxal d. Thiamine e.Biotin 3. How do each of these compounds affect the function of ATCase? a. ATP is a K effector and CTP is a V effector. b. ATP is a V effector and CTP is a K effector. c. Both ATP and CTP are K effectors. d. Both ATP and CTP are V effectors. e. none of these 4. Which of the following does not apply to the concerted model for subunit behavior: a. Each subunit can exist in a relaxed (R) and taut (T) conformation. b. All subunits will be in either the R or the T conformation at the same time. c. Some subunits can be in the R state while others are in the T state. d. The presence of inhibitors will lead to more of the enzyme being in the T form e. the presence of activators will lead to more of the enzyme being in the R form 5. In a comparison of allosteric and non-allosteric enzymes a. it is always possible to define a KM b. it is always possible to define a Vma c.competitive inhibition is always a possibility d. much of the terminology is completely unchanged 6. In the concerted model for allosteric enzymes, if the taut form of the enzyme cannot bind substrate then b. I' = R/T d. an inhibitor must be present e. none of these Pay Congage Learning esng Powered by Cogna

Explanation / Answer

1) a.They always bind at site different from the active site.The allosteric inhibitor bindsto an enzyme at a site other than the active site. The shape of the active site is altered thus the enzyme can no longer bind to its substrate.

2) a.Redox reactions often use this cofactor - Riboflavin  enzymes are only active when bound to non-protein helper molecules.

3) c.Both ATP and CTP are K effectors.

4) c. Some subunits can be in the R state while others are in the T state.Because each subunit can exist in a relaxed (R) and taut (T) conformation and all subunits will be in either the R or the T conformation at the same time both are correct.

5) b . it is always possible to define a Vmax.An activator may cause the substrate saturation become more nearly hyperbolicwith a decrease in K but no change in Vmax, thus resulting in an increased reaction velocity at a fixed substrate concentration V is higher for any value of substrate. Other allosteric enzymes respond to an activator by an increase in Vmax, with little change in K.

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