You are working with a compound called Compound X that causes pancreatic cancer

Question

You are working with a compound called Compound X that causes pancreatic cancer in dogs but not cats. If normal pancreatic cells from dogs or cats are cultured and exposed to Compound X, . neither are transformed into cancer cells. How can you explain these observations? Compound X is pre-carcinogen that can activated by liver enzymes of dogs but not cats. Cats are evolutionarily superior to dogs. Compound X is a carcinogen that activates metabolic targets causing cancer. Dogs, bud not cats, contain metabolic targets causing cancer activated by Compound X Compound X causes cancer in an organ-specific fashion. Dog pancreas, but not cat pancreas, provides necessary conditions that combined with compound X allow cancer cells to grow.

Explanation / Answer

To cause the diseases the targets have to be activated in the signal transduction pathway. Hence the correct option is third; Compound X is a carcinogen that activates metabolic targets causing cancer. Dogs but not cats, contain metabolic targets causing cancer activated by compound X.

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