If you were to replace 2-acetylpyridine with acetophenone in the Aldol Reaction

ID: 975630 • Letter: I

Question

If you were to replace 2-acetylpyridine with acetophenone in the Aldol Reaction of 2-acetylpyridine and 4-nitrobenzaldehyde, would you expect the rate of the reaction to increase, decrease, or stay they same? Why? How could you monitor this reaction to determine when it has reached completion? If you were to replace 2-acetylpyridine with acetophenone in the Aldol Reaction of 2-acetylpyridine and 4-nitrobenzaldehyde, would you expect the rate of the reaction to increase, decrease, or stay they same? Why? How could you monitor this reaction to determine when it has reached completion?

Explanation / Answer

The rate of reaction will increase because the acetophenone is more acidic than 2-acetylpyridine,

so its removed more rapidly.

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If you were to replace 2-acetylpyridine with acetophenone in the Aldol Reaction

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