During ribosome biogenesis, ribosomal protein (RP1) is assembled with rRNA in nu

Question

During ribosome biogenesis, ribosomal protein (RP1) is assembled with rRNA in nucleus. The assembled unit is translocated to the cytosol as a functional ribosomal subunit. Choose the explanation that best describes the process of ribosome biogenesis from a nuclear translocation point of view.

a) RP1 mRNA, coated with RNA binding proteins (expressing a NES) is transported out of the nucleus by exportins (Ran GTP bound). Following translation, the protein is transported to the nucleus by the interaction of its NLS with the importins. Upon assembly with rRNA, the subunit undergoes conformational change to expose the NES, which leads to an exportin (bound to RanGTP) mediated transport to the cytosol

b)   RP1 mRNA is transported to the cytoplasm by passive diffusion. RP1 is synthesized in the cytosol. Based on the NLS sequence in RP1, it binds to importins and is translocated to nucleus. RP1 is assembled with rRNA and the ribosomal subunit is exported to the nucleus by virtue of its NES.

c)   RP1 is synthesized inside the nucleus from mRNA. The synthesized protein is assembled to its cognate rRNA to reveal a NES. The complex binds to RanGTP bound exportins and translocated to the cytoplasm.

a) RP1 mRNA, coated with RNA binding proteins (expressing a NES) is transported out of the nucleus by exportins (Ran GTP bound). Following translation, the protein is transported to the nucleus by the interaction of its NLS with the importins. Upon assembly with rRNA, the subunit undergoes conformational change to expose the NES, which leads to an exportin (bound to RanGTP) mediated transport to the cytosol

Explanation / Answer

Ans: option 3rd

c)   RP1 is synthesized inside the nucleus from mRNA. The synthesized protein is assembled to its cognate rRNA to reveal a NES. The complex binds to RanGTP bound exportins and translocated to the cytoplasm

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