Which of the following statements is FALSE with regard to the process of the ope

Question

Which of the following statements is FALSE with regard to the process of the operation of the FoF1 ATP synthase in oxidative phosphorylation? The FoF1 complex contains three alpha-beta subunits that function to synthesize ATP on the beta subunit. The c subunits in the c ring rotate together as a unit around an axis perpendicular to the membrane. The alpha-beta subunits turn in conjunction with the stalk rotation to synthesize ATP. The synthesis of ATP occurs in a domain associated with the F1 component of the ATP synthase. The nucleotide binding domains in the alpha-beta subunits change conformation in association with their interaction with the rotating stalk.

Explanation / Answer

The statement "The alpha-beta subunits turn in conjunction with the stalk rotation to synthesize ATP" is incorrect

Mitochondrial F1 has nine subunits of five different types, with the composition alpha3, beta3, gamma, epsilon and psi. Each of the three subunits has one catalytic site for ATP synthesis. The polypeptides that make up the stalk in the F1 crystal structure are asymmetrically arranged, with one domain of the single gamma subunit making up a central shaft that passes through F1, and another domain of gamma associated primarily with one of the three beta subunits.

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