You are performing an experiment with intact mitochondria (refer to the graph be

Question

You are performing an experiment with intact mitochondria (refer to the graph below). You are monitoring O2 consumption (left y-axis) and ATP synthesis (right y-axis) over time (x-axis), . You introduce succinate (an oxidizable substrate) at time A, which supplies a source of electrons. You observe no change in O2 consumption or ATP synthesis. At time B, you add ADP and Pi. At time C, you add a new compound your lab has discovered. What is the best interpretation of the results you observe? Your new compound is an inhibitor of Complex III (cytochrome bc 1) and/or Complex IV (cytochrome oxidase), preventing electron transport and ATP synthesis. Your new compound is an uncoupler resulting in the dissipation of the proton gradient and no new ATP synthesis. Your new compound has no effect on electron transport or the proton gradient. Your new compound is an inhibitor of Complex I (NADH dehydrogenase), preventing electron transport to coenzyme Q. Your new compound prevents proton pumping by Complex II (succinate dehydrogenase), which results in the failure to produce a proton gradient, thus disrupting electron flow and ATP synthesis.

Explanation / Answer

E) your compound prevent proton pumping by Succinate dehydrogenase and there would no proton grading not across mitochondrial m at mbran

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