A change in gene expression is a common output of a given cell signaling pathway
ID: 97025 • Letter: A
Question
A change in gene expression is a common output of a given cell signaling pathway. Many transcription factors have been mentioned throughout this course that are activated in response to various forms of stress. Match each transcription factor with its correct description/role.
1. HIF 1 beta
[ Choose ] a.DNA damage response b. Oxidative Stress c. unfolded protein response d. hypoxia response e. gluconeogenesis f. autophagy machinery genes g. G1 arrest h. lipid uptake/storage
2. Nrf1
[ Choose ] DNA damage response Oxidative Stress unfolded protein response hypoxia response gluconeogenesis autophagy machinery genes G1 arrest lipid uptake/storage
3. ATF4
[ Choose ] DNA damage response Oxidative Stress unfolded protein response hypoxia response gluconeogenesis autophagy machinery genes G1 arrest lipid uptake/storage
4. p53
[ Choose ] DNA damage response Oxidative Stress unfolded protein response hypoxia response gluconeogenesis autophagy machinery genes G1 arrest lipid uptake/storage
5. p21
[ Choose ] DNA damage response Oxidative Stress unfolded protein response hypoxia response gluconeogenesis autophagy machinery genes G1 arrest lipid uptake/storage
6. CHOP
[ Choose ] DNA damage response Oxidative Stress unfolded protein response hypoxia response gluconeogenesis autophagy machinery genes G1 arrest lipid uptake/storage
7. FOXO1
[ Choose ] DNA damage response Oxidative Stress unfolded protein response hypoxia response gluconeogenesis autophagy machinery genes G1 arrest lipid uptake/storage
8. PPAR gamma
[ Choose ] DNA damage response Oxidative Stress unfolded protein response hypoxia response gluconeogenesis autophagy machinery genes G1 arrest lipid uptake/storage
Each one is correct for each option. Please help me as soon as possible. Thanks
Explanation / Answer
1. HIF 1 - d.Hypoxia response
2. Nrf1 - b.Oxidative Stress
3. ATF4 - f.autophagy machinery genes
4. p53 - a.DNA damage response
5. p21 - g.G1 arrest
6. CHOP - c.unfolded protein response
7. FOXO 1- e.gluconeogenesis
8. PPAR gamma - h.lipid uptake/storage
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