The chemical substance 2-acetylaminofluorene (AAF ) causes bladder cancer when i

Question

The chemical substance 2-acetylaminofluorene (AAF ) causes bladder cancer when injected into rats but not guinea pigs. If normal bladder cells obtained from rats and guinea pigs are grown in culture and exposed to AAF , neither are converted into cancer cells.

How can you explain these findings?

a) AAF is a "precarcinogen" that needs to be metabolically activated before it can cause cancer. Rats, but not guinea pigs, contain a liver enzyme that catalyzes the metabolic activation of AAF . b) AAF is a carcinogen that causes cancer in organ-specific conditions. Rats, but not guinea pigs, provide necessary conditions that combined with AAF allow cancer cells to grow. c) AAF is a carcinogen that activates metabolic targets causing cancer. Rats, but not guinea pigs, contain metabolic targets causing cancer activated by AAF .

Explanation / Answer

AAF is a "precarcinogen" that needs to be metabolically activated before it can cause cancer.

It explains why it does not cause cancer when isolated cells from either rats or guinea pigs are exposed to it.

Rats, but not guinea pigs, contain a liver enzyme that catalyzes the metabolic activation of AAF.

It explains why it causes cancer when injected into rats but not guinea pigs...

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