1)Based on the gene, mRNA and protein sequences that follow, what type of mutati
ID: 96887 • Letter: 1
Question
1)Based on the gene, mRNA and protein sequences that follow, what type of mutation-polypeptide effect has occurred?
Normal gene: TAC GCC GGC CCG AAA TTT ACT
mRNA: AUG CGG CCG GGC UUU AAA UGA
Normal protein: Methionine-Arginine-Proline-Glycine-Phenylalanine-Lysine
Mutated gene: TAC GCC GGC CCG ATA TTT ACT
mRNA: AUG CGG CCG GGC UAU AAA UGA
Protein: Methionine-Arginine-Proline-Glycine-Tyrosine-Lysine
a)base addition: change in one amino acid
b)base substitution: no change
c)base substitution: change in one amino acid
e)base deletion: change in one amino acid
2)Based on the gene, mRNA and protein sequences that follow, what type of mutation-polypeptide effect has occurred?
Normal gene: TAC GCC GGC CCG AAA TTT ACT
mRNA: AUG CGG CCG GGC UUU AAA UGA
Normal protein: Methionine-Arginine-Proline-Glycine-Phenylalanine-Lysine
Mutated gene: TAC GCC GGT CCG AAA TTT ACT
mRNA: AUG CGG CCA GGC UUU AAA UGA
Protein: Methionine-Arginine-Proline-Glycine-Phenylanine-Lysine
a)deletion: silent or no change
b)substitution: change in one amino acid
c)substitution: silent or no change
3)List the sequence of nucleotides in mRNA molecule that would be produced from the following DNA template strand during transcription.
DNA: TAC CCT GAA TGC AAA CAT GAA ATT
4) What causes induced mutations? What causes spontaneous mutations?
Explanation / Answer
1) In the amino acid sequence, phenyl aslanine in normal protein is replaced by tyrosine in the mutated protein. The mutation has caused a change in amino acid. So, this is called as base substitution mutation, which causes change in one amino acid (option c).
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