#1 - The initial events of catalysis, as represented in Panel A of the figure, i

Question

#1 - The initial events of catalysis, as represented in Panel A of the figure, include:

concerted covalent catalysis by His57 and Ser195.

covalent catalysis by His57 and concerted acid/base catalysis by Ser195.

acid catalysis by His57 and covalent catalysis by Ser195.

base catalysis by His57 and covalent catalysis by Ser195.

concerted acid/base catalysis by His57 and covalent catalysis by Ser195.

A.

concerted covalent catalysis by His57 and Ser195.

B.

covalent catalysis by His57 and concerted acid/base catalysis by Ser195.

C.

acid catalysis by His57 and covalent catalysis by Ser195.

D.

base catalysis by His57 and covalent catalysis by Ser195.

E.

concerted acid/base catalysis by His57 and covalent catalysis by Ser195.

Asp 102 His 57 Asp 102 57 CH2 CH2 Ser 195 Ser 195 N 1 CH2 CH2 Nucleophilic attack R' Substrate/ polypeptide N Tetrahedral intermediate Enzyme-substrate complex Asp 102 57 Asp 102 His 57 CH2 Ser 195 CH2 Ser 195 H20 N 1 CH2 CH2 New N-terminus of R cleaved polypeptide R chain R'NH2 N C 0 Acyl-enzyme intermediate Asp 102 His 57 Asp 102 His 57 CH2 Ser 195 CH2 Ser 195 CH2 CH2 New C-terminus of cleaved polypeptide/R chain Tetrahedral intermediate Active enzyme © 2008 John Wiley & Sons, Inc. All rights reserved.

Explanation / Answer

base catalysis by His57 and covalent catalysis by Ser195.

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