The following enzymes have important functions in signal transduction. Match the

Question

The following enzymes have important functions in signal transduction. Match the enzyme with its function. A. Adenylate cyclase B. G-protein C. Phospholipase C D. Pl-3-kinase E. Protein kinase A F. Phosphodiesterase ______ produces a second messenger in response to glucagons or epinephrine signaling. That second messenger is ____ hydrolyzes phosphatidylinositol-4, 5-bisphosphate (PIP_2) to diacylglycerol (DAG) and inositol 1, 4, 5-trisphosphate (IP_3). A hormone that uses this pathway is _____. cholera toxin covalently modifies this protein by ADP-ribosylation and inhibits its activity. What activity is inhibited by cholera toxin?_____

Explanation / Answer

1.ans) Adenylate cyclase produces a second messenger in response to glucagons or epinephrine signalling.

The second messenger is cyclic adenosine monophosphate(cAMP).

2.Ans) Phospholipace C hydrolyzes PIP2 to DAG and IP3.

Hormone that use this pathway protein kinase C and second messenger is DAG and IP3 .

3.Ans) Pi3 kinase phosphorylates PIP2 to activation of other kinases.

Hormone that uses this pathway is insulin and ovarian hormones.

4.Ans) Pertussis toxin and ctx cholera toxin covalently modifies ADP-ribosylation.

cholera toxin inhibits the activity of G proteins.

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