Which of the following are TRUE of X-inactivation? (Choose all that are true) a.

ID: 960269 • Letter: W

Question

Which of the following are TRUE of X-inactivation? (Choose all that are true)

a. In normal individuals, X-inactivation is random - the X from the male parent or female parent are equally likely to be inactivated.

b. A noncoding RNA called Tsix represses expression of the Xist loci from the active X chromosome.

c. The X chromosome contains a region known as the X-inactivation center (XIC) which produces a long noncoding Rna known as Xist.

d. Xist is expressed from one X chromosome and coats the *other* X chromosome, leading to inactivation of the coated chromosome.

The correct answers are

a. In normal individuals, X-inactivation is random - the X from the male parent or female parent are equally likely to be inactivated.

b. A noncoding RNA called Tsix represses expression of the Xist loci from the active X chromosome.

c. The X chromosome contains a region known as the X-inactivation center (XIC) which produces a long noncoding Rna known as Xist.

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