One of the reactions of glycolysis (a pathway of metabolism) involves the isomer
ID: 958761 • Letter: O
Question
One of the reactions of glycolysis (a pathway of metabolism) involves the isomerization of dihydroxyacetone phosphate (DHAP) to glyceraldehyde 3-phosphate (GAP). This reaction is a reversible (DHAP <----> GAP). When the reaction reaches equilibrium, the concentrations are: [DHAP] = 2 x 10-4 M, and [GAP] = 9.5 x 10-6 M. What are the values [write the numbers and units] for the following thermodynamic parameters? Show all work.
A) Equilibrium constant: Keq = ________
B) Reaction free energy at equilibrium: G = _________
C) Reaction free energy at standard state (T = 298K, [DHAP] = [GAP] = 1 M): Go = _________
Explanation / Answer
DHAP <-----------------> GAP
A)
[DHAP] = 2 x 10^-4 M
[GAP] = 9.5 x 10^-6 M
Keq = [GAP] / [DHAP]
= 9.5 x 10^-6 / 2 x 10^-4
= 0.0475
Keq = 0.0475
B)
Go = - RT ln Keq
= - 8.314 x 10^-3 x 298 x ln 0.0475
= 7.55 kJ/mol
Go = 7.55 kJ / mol
C)
if [DHAP] = [GAP] = 1 M then Keq =1
Go = 0
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