The overall Delta G Degree of glycolysis is -79.9 kJ/mol, while the overall Delt

Question

The overall Delta G Degree of glycolysis is -79.9 kJ/mol, while the overall Delta G Degree for gluconeogenesis is -42.7 kJ/mol. What would be the Delta G Degree of the synthesis of glucose from pyruvate if t he pathway was the reverse reactions of glycolysis? There are four enzymes that are unique to gluconeogenesis. List them in order from occurrence in the direction of pyruvate to glucose synthesis. Spelling counts, case insensitivie. Although glycolysis and gluconeogensis are reverse pathways, they are both exergonic pathways. The synthesis of glucose from pyruvate, although exergonic, is energetically expensive. If glycolysis were able to run in the reverse direction (using the same reactions), how many net ATP would be input? How many high-energy phosphate groups (as either ATP or GTP) are required for the synthesis of glucose from pyruvate by gluconeogenesis?

Explanation / Answer

For the synthesis of glucose from pyruvate by a reverse glycolysis, overall dGo would become +79.9 kJ/mol

The four enzymes unique to glucogenesis are,

pyruvate carboxylase

PEP carboxykinase

fructose bisphosphatase

glucose-6-phosphatase

If glycolysis were able to run in the reverse direction, the number of net ATP input needed are = 2

The number of high-energy phosphate group required for synthesis of glucose from pyruvate by glucogenesis = 6

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