At the molecular level, insulin receptor activation typically leads to the activ

Question

At the molecular level, insulin receptor activation typically leads to the activation of the kinase, Akt; however, there are varying outputs of this activation, depending upon the cell/tissue type. Match each insulin signaling event/output with its target cell. Some outputs may have more than one match.

A. glycogen synthase inactivation

      [ Choose ]            liver            adipose and liver            muscle and adipose            adipose            liver and muscle      

B. Rab 10-GTP forms

      [ Choose ]            liver            adipose and liver            muscle and adipose            adipose            liver and muscle      

C. SREBP-1 activates lipogenesis genes

      [ Choose ]            liver            adipose and liver            muscle and adipose            adipose            liver and muscle      

D. Hormone-sensitive lipase inhibition

      [ Choose ]            liver            adipose and liver            muscle and adipose            adipose            liver and muscle      

E. Foxo not allowed toactivate gluconeogensis genes

      [ Choose ]            liver            adipose and liver            muscle and adipose            adipose            liver and muscle      

F. PPAR gamma activates lipid uptake and storage

[ Choose ]            liver            adipose and liver            muscle and adipose            adipose            liver and muscle  

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Explanation / Answer

A . Glycogen synthase inactivation occurs in liver.

This occurs in response to the action of glucagon and epinephrine

B. Rab 10 gtp forms in muscle and adipose.

It is involved in the traslocation of glucose through different cells with the help of GLUT4 transporter.

C.SREBP-1 activates lipogenesis genes in liver,muscle and adipose.

SREDP stands for Sterol regulatory element binding protein.

It is a transcrition factor and expressed more in liver and adipose and less in muscles.

D.Hormone-sensitive lipase inhibition occurs in adipose.

Hormone sensitive lipase is involved in mobilization of stored fats.

E. Foxo not allowed to activate gluconeogensis genes in liver, muscle and adipose.

Foxo1 is a transcription factor which play a major role in gluconeogenesis and glycogenolysis.

F. PPAR gamma activates lipid uptake and storage in adipose.

PPAR stands for peroxisome proliferation activated receptor . This helps to balance the energy resources of the body by controlling the differentiation of adipocytes,storage of fatty acids, use of glucose etc

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