Hor the datnier o a aes 3. Read these instructions carefully or you will lose a
ID: 94363 • Letter: H
Question
Hor the datnier o a aes 3. Read these instructions carefully or you will lose a painful number of points on this one. For the different intracellular localizations associated with proteins listed on the LEFT, Choose one mode of translation (A, B, or C), AND one path of trafficking (1 6) associated w reniers e of translation (A, B, or C), AND one path of trafficking (1-6) associated with the best answers among the descriptions listed on the RIGHT: (14 points) Note, each protein location will have one mode of translation and one path of trafficking, any answers may be used more than once, and not all paths of trafficking will be used) Protein localization How it gets there A. Synthesis by ribosome into ER lumen B. Complete synthesis by free ribosome C. Synthesis by ribosome into ER membrane Cytosol Plasma membrane protein Mitochondrial matrix protein Lumen of the Golgi 1. Trafficking vesicles (eventually to plasma membrane 2. Stays in cytosol to perform job there 3. Trafficking vesicles (eventually to nuclear membrane) 4. Bound by nuclear import receptor, moved through x protn Nucleoplasm nuclear pour 5. Trafficking vesicles (eventually to Golgi) 6. Bound by mitochondrial membrane receptor, Nuclear membrane translocated through double membrane Exported from cellExplanation / Answer
The protein translation depends upon the functional region of protein product. Thus the ptoteins to be sent to the nucleus are translated in the ER lumen,those to be sent back to cytoplasm are translated on the ER membrane by bound ribosomes. And those to be exported to other organs or imported from cells are translated by free ribosomes.
Therefore, those synthesized into ER lumen includes nucleoplasmic and nuclear membrane proteins.The former is bound to nuclear import recetor and through the nuclear pore enters its target region the nucleoplasm.
The later are engulfed by traficking vesicles and sent to nuclear membrane where they are expressed.
The proteins completely synthesized by free ribosomes includes, mitochondrial matrix proteins(MMP), exported proteins and those in the golgi lumen. These MMPs are then translocated through the mitrchondrial membrane proteins into the matrix. Exported proteins reach plasma membrane to be released outside.And the golgi proteins reach the lumen through vesiculat transport.
The proteins synthesized by ribosomes on the ER membrane includes, cytosolic proteins and plasma membrane proteins.
The cytosolic proteins are released back into the cytosol to perform their functions whereas the plasma membrane proteins are sent to the plasma membrane via. trafficking vesicles. Since the proteins are tagged with the location specific transporter proteins during synthesis, they reach desired locations when translated by the ribosomes.
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