A new potential heart medicine, code-named X-281, is being tested by a pharmaceu

Question

A new potential heart medicine, code-named X-281, is being tested by a pharmaceutical company, Pharma-pill. As a research technician at Pharma-pill, you are told that X-281 is a monoprotic weak acid, but because of security concerns, the actual chemical formula must remain top secret. The company is interested in the drug's Ka value because only the dissociated form of the chemical is active in preventing cholesterol buildup in arteries.

To find the pKa of X-281, you prepare a 0.083 M test solution of X-281 at 25.0 C. The pH of the solution is determined to be 2.40. What is the pKa of X-281?

Explanation / Answer

let X be

HA

then

HA <--> H+ and A-

K = [H+][A-]/[HA]

if

pH = 2.4

then [H+] = 10^-pH = 10^-2.4 = 0.003981

and A- = H+ duie to stoichiometry

and

[HA] = 0.083- x = 0.083-0.003981 = 0.079019

then

KA = (0.003981 )(0.003981)/(0.079019) = 0.00020056392

pKa = -log(Ka) = -log(0.00020056392 = 3.697747

pKb = 14-pKa = 14-3.697747 = 10.302253

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