PrfA protein is a global regulator of virulence genes in Listeria, a bacterium t

Question

PrfA protein is a global regulator of virulence genes in Listeria, a bacterium that can cause severe food poisoning. Below host body temperatures PrfA mRNA exists in a conformation that hides the ribosome binding site. Upon entry into a host and a rise in temperature, hydrogen bonds in the mRNA break, exposing the ribosome binding site. What level of gene regulation is seen here? changing the DNA sequence transcription control translation control posttranslational control Bacteria regulate virulence gene expression because

Explanation / Answer

Answer is transcription control.

PrfA regulon controls the expression of virulence factors of Listeria in host cell. PrfA activity depends on a number of environmental and bacteria-derived signals which bring about the correct spatio-temporal and niche-adapted expression of the regulon with maximum induction into the host cell cytosol and repression in the environmental habitat. The gene regulation involves changes in PrfA activity-presumably by cofactor-mediation and concentration. PrfA is involved in transcriptional, translational and post-translational control mechanisms.

In the above scenario the control of the first phase of gene expression i.e., transcriptional control by PrfA has been described.

Related Questions

Navigate

• Browse (All)
• Browse P
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.