PLEASE PROVIDE YOUR RATIONALE FOR EACH ANSWER. Question II. A biochemist determi

Question

PLEASE PROVIDE YOUR RATIONALE FOR EACH ANSWER.

Question II. A biochemist determines the amino acid sequence of the entire light chain from a purified immunoglobulin produced by a patient whose genome was completely sequenced. From this sequence this scientist is able to establish [complete the sentence and assess each subsequent statement (11-19) as either factually correct (= “true”) or incorrect (= “false”)]:

11. the class of immunoglobulin.
12. the light chain isotype.
13. whether the B cell that produced this antibody received T-cell help.
14. the specific variable gene fragment used to produce this chain.
15. the antigen specificity of the immunoglobulin.
16. the number of VDJ rearrangements needed to produce this light chain.
17. the most frequent amino acid present in this light chain.
18. the most frequent amino acid most likely to be present in the associated heavy chain.
19. which antigens cannot react with this immunoglobulin.

PLEASE PROVIDE YOUR RATIONALE FOR EACH ANSWER.

PLEASE ACTUALLY ANSWER TRUE OR FALSE FOR EACH QUESTION AS WELL

Explanation / Answer

Answer : 11 : The five major classes of immunoglobulins (Ig) are IgA, IgD, IgE, IgG, and IgM.

12 : light chain could be divided into two regions based on variability in the amino acid sequences. These are the:

VL (110 amino acids) and CL (110 amino acids).

13 : True

14: true

15: False

16: true

17 : True

18 : False

19: IgM (Immunoglobulin M) antibody

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