Glomerular Filtration Rate (GFR) is maintained at a pretty constant 125 m/min in

Question

Glomerular Filtration Rate (GFR) is maintained at a pretty constant 125 m/min in spite of potentially wide swings in MAP. Which of the following could alter GFR? 1. Podocytes reducing the size & number of filtration slits and thereby reducing the coefficient of filtration (K_f) and reducing GFR. 2. Vasopressin induced vasculature contraction that reduces blood flow by increasing resistance. 3. Smooth muscle in afferent arteriole undergoing Vasoconstriction or vasodilation. 4. "Backed-up" filtrate in the nephron due to blockage of minor calyx by calcium oxalate crystals. 5. Tubuloglomerular feedback loop - macula densa cells of the DCT releasing vasoactive factors that cause changes in smooth muscle activity of afferent & efferent arterioles. 6. Any & ALL hormonal control mechanisms affecting blood pressure (MAP). a. 1, 2, 3 b. 1, 3, 5, 6 c. 2, 3, 4, 5 d. 1, 3, 4, 5, 6 e. All of the above

Explanation / Answer

The answer would be e. All the above. The reasons for the glomerular filtration rate is altered by the all the factors discussed above. The total amount of filtrate formed by kidneys per minute used to measure filtration efficiency and maintained at 120-125 ml/min. if nor well-maintained and high GFR substances are not reabsorbed by blood and low GFR everything including waste is reabsorbed. Podocytes, hormones, vasopressin, all are responsible for the change in GFR.

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